A highly regioselective direct cross-coupling of internal alkenes of α-oxoketene dithioacetals with terminal alkenes has been successfully realized by palladium-catalyzed CH bond activation, affording functionalized 1,3-butadienes. Condensation of the resultant 1,3-butadienes by diamines efficiently produced potentially bioactive bicyclic pyridone derivatives (see scheme).
No takes yet. Share an insight, caveat, or question.
Yu et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: