Chemical synthesis study reveals catalyst-controlled regiodivergent reactions of ynones with trifluoromethyl ketones, indicating streamlined access to diverse fluorinated building blocks.
A novel NHC-catalyzed regiodivergent reaction of ynones with trifluoromethyl ketones consisting of Aldol reactions and intermolecular [3 + 2] annulations has been developed. Employing two different NHC catalysts, various tertiary alcohols and dihyrofuranones containing trifluoromethyl can be obtained in moderate to good yields (35 examples, up to 91% yield). This protocol features mild reaction conditions, high efficiency and broad substrates scope, promoting the development of NHC catalysis and transformations of ynones.
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Lu et al. (2023) studied this question.
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