Naturally catalytic: The cinchonidine- and cinchonine-derived bifunctional thiourea organocatalysts 1 a and 1 g (see picture) have been applied in the asymmetric hydrophosphonylation of aromatic and heteroaromatic α-ketoesters for the first time, obtaining S and R products in high yields with good to excellent enantioselectivities (up to 91 % ee).
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Wang et al. (2008) studied this question.
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