Key result
Circulating and lesional skin miR-200c levels were upregulated in patients with severe psoriasis compared to controls and positively correlated with left ventricular mass and relative wall thickness.
Why the study?
Psoriasis is linked to reactive oxygen species and cardiovascular risk, prompting investigation into whether miR-200 family members are modulated in skin and plasma and correlate with cardiovascular risk determinants.
Case-Control (n=70)
miR-200c is upregulated in severe psoriasis and correlates with subclinical markers of cardiovascular risk and diastolic dysfunction, suggesting a mechanistic link between psoriasis-associated inflammation and cardiovascular disease.
Answers are grounded in this paper and cite their sources.
miR-200c may flag subclinical cardiac risk in psoriasis; hypothesis-generating and leaves open causal or biomarker roles pending validation.
Psoriasis is a chronic inflammatory skin disease associated with reactive oxygen species (ROS) increase and a higher risk of cardiovascular (CV) events. We previously showed that the miR-200 family (miR-200s) is induced by ROS, miR-200c being the most upregulated member responsible for apoptosis, senescence, ROS increase, and nitric oxide decrease, finally causing endothelial dysfunction. Moreover, circulating miR-200c increases in familial hypercholesterolemic children and in plaques and plasma of atherosclerotic patients, two pathologies associated with increased ROS. Given miR-200s’ role in endothelial dysfunction, ROS, and inflammation, we hypothesized that miR-200s were modulated in lesional skin (LS) and plasma of psoriatic patients (Pso) and that their levels correlated with some CV risk determinants at a subclinical level. All Pso had severe psoriasis, i.e., Psoriasis Area and Severity Index PASI>10 , and one of the following: at least two systemic psoriasis treatments, age at onset<40 years , and disease duration>10 years . RNA was extracted from plasma (Pso, N=29 ; Ctrl, N=29 ) and from nonlesional skin (NLS) and LS of 6 Pso and 6 healthy subject skin (HS) biopsies. miR-200 levels were assayed by quantitative RT-PCR. We found that all miR-200s were increased in LS vs. NLS and miR-200c was the most expressed and upregulated in LS vs. HS. In addition, circulating miR-200c and miR-200a were upregulated in Pso vs. Ctrl. Further, miR-200c positively correlated with PASI, disease duration, left ventricular (LV) mass, LV relative wall thickness (RWT), and E/e′ , a marker of diastolic dysfunction. Multiple regression analysis indicates a direct association between miR-200c and both RWT and LV mass. Circulating miR-200a correlated positively only with LV mass and arterial pressure augmentation index, a measure of stiffness, although the correlations were nearly significant ( P=0.06 ). In conclusion, miR-200c is upregulated in LS and plasma of Pso, suggesting its role in ROS increase and inflammation associated with CV risk in psoriasis.
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Magenta et al. (2019) conducted a case-control in Psoriasis (n=70). Severe psoriasis vs. Healthy controls was evaluated on miR-200c levels and correlation with cardiovascular risk determinants. Circulating and lesional skin miR-200c levels were upregulated in patients with severe psoriasis compared to controls and positively correlated with left ventricular mass and relative wall thickness.
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