Key result
Time-averaged serum potassium levels below 4.0 mEq/L were associated with a significantly higher risk of all-cause mortality (HR 1.743) compared to levels of 4.0 mEq/L or higher in peritoneal dialysis patients.
Why the study?
Does time-averaged serum potassium level and its fluctuation predict long-term survival in peritoneal dialysis patients?
Population
357 incident peritoneal dialysis (PD) patients
Comparison
Time-averaged serum potassium levels and its… vs Baseline serum potassium level, and different…
Design
Cohort
Follow-up
Up to approximately 7 years
Authors
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May inform risk stratification in peritoneal dialysis; hypothesis-generating for trials targeting potassium stability.
Cohort (n=357)
Yes
Does time-averaged serum potassium level and its fluctuation predict long-term survival in peritoneal dialysis patients?
Hazard Ratio: 1.743 (95% CI 1.046–2.906)
Absolute Event Rate: 29.2% vs 15.2%
p-value: p=0.033
Both lower time-averaged serum potassium levels and greater fluctuations in these levels are associated with increased all-cause and cardiovascular mortality in peritoneal dialysis patients.
Li et al. (2015) conducted a cohort in Peritoneal dialysis (End-stage renal disease) (n=357). Time-averaged serum potassium < 4.0 mEq/L vs. Time-averaged serum potassium ≥ 4.0 mEq/L was evaluated on All-cause mortality (HR 1.743, 95% CI 1.046-2.906, p=0.033). Time-averaged serum potassium levels below 4.0 mEq/L were associated with a significantly higher risk of all-cause mortality (HR 1.743) compared to levels of 4.0 mEq/L or higher in peritoneal dialysis patients.
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