Peri-ictal lateralizing signs in children: Blinded multiobserver study of 100 children ≤12 years

Seizures in 100 children with partial epilepsy, 61% of temporal lobe origin, were assessed by multiple observers for lateralizing signs (LSs). Most LSs achieved very good interobserver agreement and high predictive value. Seventy-five percent of children produced LSs. Lack of LSs occurred more frequently among younger children, while some LSs appeared more frequently at older ages. Many frequent and reliable LSs were independent of age. LSs may help in the presurgical evaluation of infants and young children.