Oral Vitamin B12 without Intrinsic Factor in the Treatment of Pernicious Anemia

Article1 May 1963Oral Vitamin B12 without Intrinsic Factor in the Treatment of Pernicious AnemiaS. O. WAIFE, M.D., F.A.C.P., C. J. JANSEN JR., M.D., R. E. CRABTREE, PH.D., E. L. GRINNAN, PH.D., P. J. FOUTS, M.D., F.A.C.P.S. O. WAIFE, M.D., F.A.C.P., C. J. JANSEN JR., M.D., R. E. CRABTREE, PH.D., E. L. GRINNAN, PH.D., P. J. FOUTS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-5-810 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the discovery of vitamin B12as the essential hematopoietic factor deficient in patients with pernicious anemia in relapse, there have been a number of studies using crystalline cyanocobalamin, without intrinsic factor, in oral therapy. Doses of less than 30 micrograms a day generally have been unsuccessful (1). Suboptimal responses have been reported on doses of up to 100 micrograms a day (1, 2). Better results have followed administration of still larger amounts—as much as 1,000 micrograms a day (3). Other schedules have been used, for example, 1,000 micrograms (1 milligram) once a week (3-7). In Table 1, we have...References1. BRODYESTRENWASSERMAN EASLR: Treatment of pernicious anemia by oral administration of vitamin B12 without added intrinsic factor. New Engl. J. Med. 260: 361, 1959. CrossrefMedlineGoogle Scholar2. CHALMERSSHINTON JNNK: Absorption of orally administered vitamin B12 in pernicious anaemia. Lancet 2: 1298, 1958. CrossrefMedlineGoogle Scholar3. MCINTYREHAHNMASTERSKREVANS PARJMJR: Treatment of pernicious anemia with orally administered cyanocobalamin (vitamin B12). Arch. Intern. Med. 106: 280, 1960. CrossrefGoogle Scholar4. REISNERWEINERSCHITTONEHENCK EHLMTEA: Oral treatment of pernicious anemia with vitamin B12 without intrinsic factor. New Engl. J. Med. 253: 502, 1955. CrossrefMedlineGoogle Scholar5. 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GLASSSKEGGSLEEJONESHARDY GBHRDHELWW: Applicability of hydroxocobalamin as a long-acting vitamin B12 in man, in Vitamin B12 und Intrinsic Factor: Europäisches Symposion, Hamburg 1961, Ferdinand Enke, Stuttgart, 1962, p. 673. Google Scholar24. HEINRICHGABBE HCEE: Internal retention and excretion of aquocobamide, a depot-form of natural vitamin B12 suitable for therapy. Klin. Wschr. 39: 689, 1961. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: S. O. WAIFE, M.D., F.A.C.P.; C. J. JANSENJR., M.D.; R. E. CRABTREE, PH.D.; E. L. GRINNAN, PH.D.; P. J. FOUTS, M.D., F.A.C.P.Affiliations: Indianapolis, IndianaFrom the Lilly Research Laboratories and the Lilly Laboratory for Clinical Research, Indianapolis, Indiana.Presented at the IX Congress of the International Society of Hematology, Mexico D. F., September, 1962.Requests for reprints should be addressed to S. O. Waife, M.D., Medical Editorial Department, Lilly Research Laboratories, Indianapolis 6, Indiana. 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Part IIAnemia and heart diseaseStudies of the small-intestinal bacterial flora and of intestinal absorption in pernicious anemia 1 May 1963Volume 58, Issue 5Page: 810-817KeywordsAnemiaClinical laboratoriesCyanocobalaminExcretionHematology and oncologyPernicious anemiaResearch laboratories ePublished: 1 December 2008 Issue Published: 1 May 1963 PDF downloadLoading ...