Key result
Staufen1 directly represses MyoD translation in muscle stem cells in vivo, maintaining their quiescent state and preventing premature cell cycle entry.
Staufen1 directly represses MyoD translation to maintain muscle stem cell quiescence, allowing cells to remain poised for activation.
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Staufen1 repression of MyoD sustains muscle stem cell quiescence; leaves open therapeutic targeting in regeneration.
Significance This work addresses a fundamental mechanism for the translational control of a master regulator of myogenic differentiation, MyoD, by the RNA binding protein Staufen1. We show that muscle stem cells express the MyoD transcript in the quiescent state in vivo but block its translation through direct repression by Staufen1. Loss of this translational repression leads to MyoD translation and cell cycle entry, highlighting a novel role for MyoD in regulating the exit from quiescence. This mechanism of direct translational repression enables the cells to exist poised for activation and cell cycle entry. These data provide insight in the translational control of muscle stem cell quiescence.
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Morrée et al. (2017) studied Muscle stem cell quiescence. Staufen1 was evaluated on MyoD translation and cell cycle entry. Staufen1 directly represses MyoD translation in muscle stem cells in vivo, maintaining their quiescent state and preventing premature cell cycle entry.
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