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The orotic acid requirement of Lactobacillus bulgaricus 09 can be met by ureidosuccinic acid (10-20% as active as orotic acid) or by 5-(carboxy-methylidine)-hydantoin (30-40% as active as orotic acid but not by any one of a large group of lated or unrelated compounds studied. The data are taken as microbiological evidence that ureidosuccinic acid and possibly ureidofumaric acid (derived from 5-(carboxy-methylidine)-hydantoin) are precursors of the pyrimidine ring.
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Wright et al. (1950) studied this question.
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