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Employment of trypsin for C(sp3)‐H functionalization to construct a new C‐C bond utilizing 2‐methylbenzothiazole/2‐methyl benzoxazole with diones has been explored. This novel and greener approach have been effectively utilized to afford bioactive 3‐substituted‐3‐Hydroxy‐2‐oxindoles. Furthermore, the presented method combines the enzyme promiscuity and C‐H functionalization which open up and expands the repertoire of chemoenzymatic C‐H functionalization.
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Shukla et al. (2019) studied this question.
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