This is the first reported case of postirradiation laryngeal osteosarcoma, highlighting the potential need for adjunctive therapies in addition to surgery.
Surgery alone may be inadequate for postirradiation laryngeal osteosarcoma; hypothesis-generating for adjunctive therapy trials in this rare entity.
BACKGROUND: Laryngeal sarcoma is a rare disease entity. In review of the literature, chondrosarcoma is the most common sarcoma, followed by fibrosarcoma. Osteosarcoma is very rare; there are only seven cases reported in the literature. Postirradiation sarcoma is a late complication of radiotherapy. Osteosarcoma is the most common type in this group. The larynx is often involved in the radiation field of treatment for head and neck malignancies. However, postirradiation laryngeal osteosarcoma has not yet been reported. METHODS: We present a 56-year-old man who under went radiotherapy for nasopharyngeal carcinoma 32 years ago and later developed a laryngeal osteosarcoma. RESULTS: The patient underwent total laryngectomy but died 1 year and 9 months later with locally extensive disease. CONCLUSIONS: We report the first case of postirradiation laryngeal osteosarcoma. In addition to surgical treatment, adjunctive therapies should be considered for this group of patients.
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Sheen et al. (1997) studied this question.
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