Acetaminophen, Alcohol, and Cytochrome P-450

Editorials1 March 1986Acetaminophen, Alcohol, and Cytochrome P-450MARTIN BLACK, M.D., JUDY RAUCY, Ph.D.MARTIN BLACK, M.D., JUDY RAUCY, Ph.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-104-3-427 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAcetaminophen (N-acetyl-p-aminophenol) was first synthesized in the late 19th century (along with acetanilide and phenacetin) and, after recognition of its mild analgesic-antipyretic properties, has been variably used in humans ever since. Although its use was not as great as that of its analog, phenacetin, over the first half of the 20th century, this situation reversed itself in the 1960s and 1970s as phenacetin was increasingly incriminated as a cause of chronic renal injury (1). 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Author, Article, and Disclosure InformationAffiliations: Temple University School of Medicine Philadelphia, Pennsylvania PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByBiomarkers of Drug-Induced Liver ToxicityAre some people at increased risk of paracetamol-induced liver injury? 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Watkins, MDMechanism of ethanol induced hepatic injuryDrug-induced Liver DiseaseHypoglycemia Associated with Liver Disease and EthanolToxic and Drug-Induced HepatitisEthanol as enzyme inducer and inhibitorTHE SPECTRUM OF HEPATOTOXICITY DUE TO DRUGS 1 March 1986Volume 104, Issue 3Page: 427-429KeywordsAlcoholsAspirinPain Issue Published: 1 March 1986 PDF DownloadLoading ...