Why the study?
Is phosphatidylethanol synthesis elevated in lymphocytes of adult males with alcohol dependency and a family history of alcoholism compared to controls?
Is phosphatidylethanol synthesis elevated in lymphocytes of adult males with alcohol dependency and a family history of alcoholism compared to controls?
Phosphatidylethanol synthesis in lymphocytes is significantly elevated in alcohol-dependent males with a family history of alcoholism, suggesting its potential as a biological marker for alcoholism risk.
Elevated lymphocyte phosphatidylethanol was associated with alcohol dependency; hypothesis-generating for biomarker potential and should not yet change practice.
Phosphatidylethanol, whose synthesis is catalyzed by a phospholipase D in a transphosphatidylation reaction, is a unique metabolite of ethanol. Phorbol 12-tetradecanoate 13-acetate, a tumor-promoting phorbol ester and stimulator of protein kinase C, activates this enzyme in peripheral blood lymphocytes. This system has been developed into an assay for measuring the potential of this pathway in human subjects. A pilot study of phosphatidylethanol synthesis in lymphocytes of adult males who have both an alcohol dependency and a family history of alcoholism has revealed that the average potential for phosphatidylethanol synthesis in this population is significantly elevated over that of control subjects.
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Mueller et al. (1988) studied this question.
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