A conformationally-immobilized calix[6]arene (2) was synthesized for the first time. The immobilization was attained by capping calix[6]aryl 1,3,5-tricarboxylic acid chloride with C3-symmetrical triol. The 1H NMR spectral examination with 2D EXSY established that 2 is immobilized in a cone conformation. Compound 2 showed the high affinity for guanidinium ion because of rigidification of the conformation.
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Araki et al. (1994) studied this question.
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