The aim of the present work was to develop and characterize biohybrid hydrogels containing combinations of gelatin and chondroitin sulphate. Two approaches have been compared. First, physisorption of chondroitin sulphate to gelatin hydrogels was investigated using surface plasmon resonance measurements. Due to the limited interaction between both biopolymers, we developed in a second approach methacrylate‐modified chondroitin sulphate hydrogels as such or in combination with methacrylamide‐modified gelatin. Rheology measurements indicated that following this approach, mechanically stable hydrogel films could be obtained after UV irradiation in the presence of Irgacure 2959 as UV photo‐initiator. When keeping the gelatin concentration and the modification degree constant, an increase in derivatization of the chondroitin sulphate component resulted in a high increase of the storage modulus.
No takes yet. Share an insight, caveat, or question.
Vlierberghe et al. (2011) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: