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A series of O,O-dialkyl 1-(3-trifluoromethylphenoxyacetoxy)-1-substituted methylphosphonates were synthesized by the condensation of O,O-dialkyl 1-hydroxyalkylphosphonates with 3-trifluoromethylphenoxyacetyl chloride. Their herbicidal activity against a set of weed species was examined. The results showed that improvement of herbicidal activity required a reasonable combination of substituents in the parent structure, which provided some hints for further study of structure modification.
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He et al. (2007) studied this question.
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