Defining Sarcopenic Obesity in the Asian Working Group for Sarcopenia 2025 Era: Diagnostic Precision Matters ― Reply ―

Q: What does this research mean for the field?

Due to limited statistical power, the lack of a statistically significant difference in outcomes between newly classified and persistent sarcopenic obesity using AWGS 2025 thresholds cannot be interpreted as clinical equivalence. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yuta Ozaki

doi:10.1253/circj.cj-26-0925

August 31, 2026Circulation JournalOpen Access

Defining Sarcopenic Obesity in the Asian Working Group for Sarcopenia 2025 Era: Diagnostic Precision Matters ― Reply ―

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Key Points

Clarify typographical errors and address correspondence regarding the statistical interpretation of equivalence between newly classified and persistent sarcopenic obesity subgroups under the AWGS 2025 framework.
Application of Asian Working Group for Sarcopenia 2025 diagnostic thresholds to categorize sarcopenic obesity.
Exploratory survival analysis comparing newly classified and persistent sarcopenic obesity groups in a modest sample cohort.
The exploratory comparison between newly classified and persistent sarcopenic obesity yielded a hazard ratio of 0.748 (95% CI, 0.254–2.204).
Because no formal equivalence or noninferiority testing was conducted and sample size limited power, the wide confidence intervals do not exclude clinically meaningful differences between groups.

Implication

Author reply clarifies risk estimates between reclassified sarcopenic obesity groups, indicating wide confidence intervals preclude claims of equivalence.

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Cite This Study

Yuta Ozaki (2026) studied this question.

synapsesocial.com/papers/6a9934b4636c6408cfa7c7d1 https://doi.org/10.1253/circj.cj-26-0925

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Defining Sarcopenic Obesity in the Asian Working Group for Sarcopenia 2025 Era: Diagnostic Precision Matters ― Reply ―

Key Points

Implication

Abstract

Discussion

Cite This Study

Defining Sarcopenic Obesity in the Asian Working Group for Sarcopenia 2025 Era: Diagnostic Precision Matters ― Reply ―

Key Points

Implication

Abstract

Discussion

Cite This Study

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