What does this research mean for the field?

Klotho deficiency exacerbates post-myocardial infarction heart failure by disrupting extracellular matrix homeostasis and downregulating ALDH1L1-mediated one-carbon metabolism and NADPH regeneration. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the mechanisms by which Klotho deficiency influences extracellular matrix homeostasis and metabolic regulation, specifically ALDH1L1-related pathways, in post-myocardial infarction heart failure.

September 3, 2026Experimental GerontologyOpen Access

Integrated transcriptomic and proteomic analysis reveals ECM disruption and ALDH1L1-linked metabolic remodeling in klotho-deficient post-infarction heart failure

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Authors

BZBing Zhao CXChun Xiao

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Implication

Murine multi-omics study reveals ALDH1L1 downregulation and extracellular matrix disruption in klotho-deficient heart failure, indicating a key metabolic role in cardiac remodeling.

Key Points

To investigate the mechanisms by which Klotho deficiency influences extracellular matrix homeostasis and metabolic regulation, specifically ALDH1L1-related pathways, in post-myocardial infarction heart failure.
Evaluated wild-type, Klotho haploinsufficient (Klotho+/-), post-myocardial infarction heart failure (MI-HF), and Klotho+/- -MI-HF mouse models.
Conducted integrated transcriptomic and proteomic profiling followed by KEGG pathway enrichment analyses.
Klotho haploinsufficiency alone produced 84 differentially expressed genes and 311 differentially expressed proteins enriched in extracellular matrix pathways compared with wild-type controls.
Comparison between Klotho+/- -MI-HF and MI-HF models identified 201 differentially expressed proteins with significant enrichment in one-carbon metabolism and NADPH regeneration pathways, characterized by marked ALDH1L1 downregulation.

Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a9934cf636c6408cfa7c80b https://doi.org/10.1016/j.exger.2026.113307

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Implication

Murine multi-omics study reveals ALDH1L1 downregulation and extracellular matrix disruption in klotho-deficient heart failure, indicating a key metabolic role in cardiac remodeling.

Integrated transcriptomic and proteomic analysis reveals ECM disruption and ALDH1L1-linked metabolic remodeling in klotho-deficient post-infarction heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Integrated transcriptomic and proteomic analysis reveals ECM disruption and ALDH1L1-linked metabolic remodeling in klotho-deficient post-infarction heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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