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Molecular study demonstrates phase separation of the core Hippo kinase module, indicating that biomolecular condensates enhance signaling efficiency and pathway control.
, while the core mammalian Ste20-like (MST)/Salvador (SAV)/large tumor suppressor (LATS) kinase module itself forms evolutionarily conserved condensates that enhance signaling efficiency. These findings establish phase separation as a central organizing mechanism in Hippo signaling and suggest a broader paradigm in which condensates provide spatial, temporal, and functional control of diverse signaling pathways.
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Zhu et al. (2026) studied this question.
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