Effect of repeated local minocycline delivery on radiographic bone levels in the non-surgical treatment of peri-implantitis: a retrospective study

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Repeated local application of minocycline during non-surgical treatment of peri-implantitis is associated with long-term radiographic bone level improvement, with outcomes varying by patient sex, implant location, and adjacent disease status. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

G H Park; Shin-Kyu Lee; Ji‐Young Joo; Ju Youn Lee; Hyun‐Joo Kim

doi:10.14368/jdras.2026.42.3.213

August 31, 2026Journal of Dental Rehabilitation and Applied ScienceOpen Access

Effect of repeated local minocycline delivery on radiographic bone levels in the non-surgical treatment of peri-implantitis: a retrospective study

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Key Points

To evaluate the long-term effect of repeated local application of minocycline on radiographic bone level changes in patients undergoing non-surgical treatment for peri-implantitis over at least 6 months.
Conducted a retrospective analysis of 28 patients (61 implants) diagnosed with peri-implantitis who received repeated local minocycline applications and had standardized periapical radiographs with ≥6 months of follow-up.
Evaluated bone changes by measuring the distance between the implant shoulder and coronal bone crest (DIB) on mesial and distal aspects, adjusting for radiographic distortion using actual implant length.
Mean radiographic bone level improvement (ΔDIB) across all implants was 1.17 ± 6.71 mm from baseline to endpoint after at least 6 months of follow-up.
Greater bone level gains occurred in male patients compared to female patients and in anterior implants compared to posterior implants, whereas adjacent peri-implantitis involvement was associated with smaller improvements.

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Implication

Retrospective study observes radiographic bone level improvements in peri-implantitis patients treated with repeated local minocycline, suggesting clinical utility in non-surgical therapy.

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Park et al. (2026) studied this question.

synapsesocial.com/papers/6a993503636c6408cfa7cc54 https://doi.org/10.14368/jdras.2026.42.3.213

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Effect of repeated local minocycline delivery on radiographic bone levels in the non-surgical treatment of peri-implantitis: a retrospective study

Key Points

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Implication

Discussion

Cite This Study

Effect of repeated local minocycline delivery on radiographic bone levels in the non-surgical treatment of peri-implantitis: a retrospective study

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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