Immune licensing of exercise: B cells wire a liver–muscle glutamate axis

Q: What does this research mean for the field?

B cells regulate exercise capacity by mediating a liver-muscle glutamate axis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yiqi Yu; Rong Rong; Weiwei Dai

doi:10.1093/jmcb/mjag036

September 1, 2026Journal of Molecular Cell BiologyOpen Access

Immune licensing of exercise: B cells wire a liver–muscle glutamate axis

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Key Points

To investigate how immune cells regulate metabolic crosstalk between the liver and skeletal muscle during exercise.
Evaluated the mechanistic link between immune cell activity and inter-organ metabolic signaling.
Tracked liver–muscle communication mediated by glutamate pathways under exercise conditions.
B cells coordinate inter-organ signaling by establishing a functional glutamate axis between the liver and muscle.
Immune activation by B cells functions as a necessary regulatory licensing step to support metabolic adaptations during exercise.

Implication

Mechanistic study uncovers B cells coordinating a liver–muscle glutamate axis, indicating an immune licensing role during exercise.

Abstract

Yiqi Yu, Rong Rong, Weiwei Dai; Immune licensing of exercise: B cells wire a liver–muscle glutamate axis, Journal of Molecular Cell Biology, , mjag036, htt

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a99351f636c6408cfa7d0d4 https://doi.org/10.1093/jmcb/mjag036

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Immune licensing of exercise: B cells wire a liver–muscle glutamate axis

Key Points

Implication

Abstract

Discussion

Cite This Study

Immune licensing of exercise: B cells wire a liver–muscle glutamate axis

Key Points

Implication

Abstract

Discussion

Cite This Study

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