Clinical review outlines diagnostic pathways for gluten- and wheat-related disorders in adults, highlighting the need for systematic evaluation to guide appropriate clinical management.
Key Points
To delineate a systematic evaluation strategy for distinguishing celiac disease from wheat allergy and nonceliac gluten and wheat sensitivity in adults.
Reviewed clinical features and differential diagnostic approaches for gluten- and wheat-related disorders.
Synthesized evidence into comparative reference tables and clinical diagnostic algorithms.
Celiac disease, wheat allergy, and nonceliac gluten and wheat sensitivity present with overlapping symptoms despite having distinct underlying mechanisms.
A structured clinical evaluation is necessary to achieve an accurate diagnosis and prevent inappropriate management across healthcare settings.