Validity of animal models in haemodialysis research: a systematic review and meta-analysis

Joost de Vries; Isabella Nguyen; Kimberley E. Wever; Masaomi Nangaku; Marianne C. Verhaar; Karin G. F. Gerritsen; Merle M. Krebber

doi:10.5281/zenodo.22208038

September 1, 2026Open Access

Validity of animal models in haemodialysis research: a systematic review and meta-analysis

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Key Points

Evaluate the translational validity, physiological concordance, and methodological quality of animal models used in haemodialysis investigations.
Conducted a systematic literature search across biomedical databases to identify preclinical animal studies investigating haemodialysis.
Extracted study characteristics and performed meta-analytic synthesis to assess model reproducibility, biological relevance, and experimental consistency across species.
Synthesizes comparative evidence regarding how accurately different animal species reproduce human haemodialysis kinetics and vascular access dynamics.
Identifies methodological strengths and recurring translational gaps in reporting quality, species selection, and physiological monitoring across preclinical haemodialysis studies.

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Implication

Systematic review and meta-analysis evaluates the translational validity of animal models in haemodialysis, highlighting key methodological considerations for preclinical kidney research.

Abstract

pre-print of manuscript "Validity of animal models in haemodialysis research: a systematic review and meta-analysis"

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Vries et al. (2026) studied this question.

synapsesocial.com/papers/6a993547636c6408cfa7d706 https://doi.org/10.5281/zenodo.22208038

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Validity of animal models in haemodialysis research: a systematic review and meta-analysis

Key Points

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Discussion

Cite This Study

Validity of animal models in haemodialysis research: a systematic review and meta-analysis

Key Points

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Implication

Abstract

Discussion

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