Animal study reveals polystyrene nanoplastics reduce splenic immune cells and alter dendritic, macrophage, and B cell populations in mice, suggesting perturbed immune homeostasis.
effect of PS-NPs on immune cell development further, 3-week-old mice were administered water containing PS-NPs for 3 weeks. Subsequent analysis of various immune cells in the thymus, bone marrow, and spleen revealed a decrease in cell numbers in the spleen following PS-NP treatment, as well as changes in the composition of conventional dendritic cells, macrophages, and B cells. These findings suggest that PS-NPs can perturb immune cell-associated responses and homeostasis.
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Dan et al. (2026) studied this question.
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