What does this research mean for the field?

Injectable thermoresponsive hydrogels offer a promising approach for localized drug delivery by prolonging local residence time and reducing systemic exposure, though significant translational challenges remain regarding gelation control, stability, and manufacturing. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the physical mechanisms, preclinical in vivo applications, and translational challenges of injectable thermoresponsive hydrogels designed for localized drug delivery.

September 3, 2026Journal of Functional BiomaterialsOpen Access

Injectable Thermoresponsive Hydrogels for Localized Drug Delivery: Mechanisms, In Vivo Evidence and Translational Challenges

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Authors

MMMiriam Di Martino LSLucia Sessa GPGiulia Pagliari

Discussion

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Overview

Narrative review reveals that injectable thermoresponsive hydrogels enhance localized drug retention across preclinical models, indicating substantial potential for targeted depot therapy.

Key Points

To review the physical mechanisms, preclinical in vivo applications, and translational challenges of injectable thermoresponsive hydrogels designed for localized drug delivery.
Synthesized literature on thermoresponsive polymer networks, including PNIPAM, poloxamers, PEG/polyester block copolymers, chitosan, and glycosaminoglycan composites.
Assessed preclinical evidence across therapeutic indications comprising cancer therapy, wound healing, osteoarthritis, and cardiac repair.
Thermoresponsive formulations successfully maintain local drug depot residence, attenuate systemic exposure, and facilitate sustained release of unstable or poorly soluble therapeutic payloads.
Significant translational bottlenecks persist in fine-tuning gelation kinetics, maintaining long-term mechanical stability, managing degradation byproducts, and establishing scalable manufacturing protocols.

Cite This Study

Martino et al. (2026) studied this question.

synapsesocial.com/papers/6a993586636c6408cfa7dc86 https://doi.org/10.3390/jfb17090436

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September 3, 2026Journal of Functional BiomaterialsOpen Access

Injectable Thermoresponsive Hydrogels for Localized Drug Delivery: Mechanisms, In Vivo Evidence and Translational Challenges

View Full Paper

Ask AI

Bookmark

Authors

MMMiriam Di Martino LSLucia Sessa GPGiulia Pagliari

Discussion

Member takes

Overview

Narrative review reveals that injectable thermoresponsive hydrogels enhance localized drug retention across preclinical models, indicating substantial potential for targeted depot therapy.

Key Points

To review the physical mechanisms, preclinical in vivo applications, and translational challenges of injectable thermoresponsive hydrogels designed for localized drug delivery.
Synthesized literature on thermoresponsive polymer networks, including PNIPAM, poloxamers, PEG/polyester block copolymers, chitosan, and glycosaminoglycan composites.
Assessed preclinical evidence across therapeutic indications comprising cancer therapy, wound healing, osteoarthritis, and cardiac repair.
Thermoresponsive formulations successfully maintain local drug depot residence, attenuate systemic exposure, and facilitate sustained release of unstable or poorly soluble therapeutic payloads.
Significant translational bottlenecks persist in fine-tuning gelation kinetics, maintaining long-term mechanical stability, managing degradation byproducts, and establishing scalable manufacturing protocols.

Cite This Study

Martino et al. (2026) studied this question.

synapsesocial.com/papers/6a993586636c6408cfa7dc86 https://doi.org/10.3390/jfb17090436

View Full Paper

Ask AI

Bookmark