What does this research mean for the field?

A distinct Procr+, Cdh5–, Col1a1+ subpopulation of mammary epithelial cells possesses stem-like properties driven by specific transcriptional regulatory circuits, and its molecular signature is conserved in humans and enriched in aggressive breast cancer subtypes. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To characterize the functional heterogeneity, transcriptional regulatory circuits, and oncogenic relevance of rare PROCR+ mammary stem-like cells across development.

September 3, 2026iScienceOpen Access

Single-cell multi-omic profiling of heterogeneous PROCR+ cells in mouse mammary gland and its implication for breast cancer

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Authors

KYKoon‐Kiu YanSt. Jude Children's Research Hospital ENErin Nekritz ZXZhen XieSt. Jude Children's Research Hospital

Discussion

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Implication

Single-cell multi-omic profiling reveals distinct PROCR+ stem cell subpopulations in mammary tissue, highlighting regulatory circuits linked to triple-negative breast cancer aggressiveness.

Key Points

To characterize the functional heterogeneity, transcriptional regulatory circuits, and oncogenic relevance of rare PROCR+ mammary stem-like cells across development.
Integrated targeted cell enrichment with single-cell transcriptomic and single-cell chromatin accessibility profiling across mouse mammary developmental stages.
Performed cross-species comparative analyses using human mammary epithelial tissue and clinical breast cancer genomic profiles.
Identified heterogeneous PROCR+ subpopulations, notably a Procr+, Cdh5–, Col1a1+ subset exhibiting high developmental potency, an early differentiation position, and an EMT-associated program consistent with mammary stem cells.
Mapped dynamic transcriptional circuits governing stemness and demonstrated that the mammary stem cell signature is specifically enriched in aggressive human triple-negative and claudin-low tumors.

Cite This Study

Yan et al. (2026) studied this question.

synapsesocial.com/papers/6a993586636c6408cfa7dcf0 https://doi.org/10.1016/j.isci.2026.117410

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Implication

Single-cell multi-omic profiling reveals distinct PROCR+ stem cell subpopulations in mammary tissue, highlighting regulatory circuits linked to triple-negative breast cancer aggressiveness.

Single-cell multi-omic profiling of heterogeneous PROCR+ cells in mouse mammary gland and its implication for breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Single-cell multi-omic profiling of heterogeneous PROCR+ cells in mouse mammary gland and its implication for breast cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

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