Proteomic Studies of Pathogenic Fungi and Hosts: A Multidisciplinary Approach to Therapeutics, Diagnostics, and Host Interactions

Q: What does this research mean for the field?

Proteomic studies provide a multidisciplinary approach essential for advancing therapeutics, diagnostics, and the understanding of host interactions in pathogenic fungi. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Lucélia Santi; Walter O. Beys‐da‐Silva

doi:10.3390/jof12090647

September 1, 2026Journal of FungiOpen Access

Proteomic Studies of Pathogenic Fungi and Hosts: A Multidisciplinary Approach to Therapeutics, Diagnostics, and Host Interactions

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Key Points

To review the multidisciplinary applications of proteomics in understanding fungal biology, host-pathogen interactions, diagnostic biomarker discovery, and antifungal drug development.
Synthesized current literature examining high-throughput proteomic technologies applied to pathogenic fungi and host immune responses.
Evaluated analytical mass spectrometry workflows that profile fungal proteomes, post-translational modifications, and host defense mechanisms.
Proteomic profiling characterizes essential fungal virulence traits, stress-response proteins, and metabolic adaptation during invasive host colonization.
Identification of specific fungal surface antigens and secretomes provides viable biomarker candidates for rapid diagnostics and novel antifungal drug targets.

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Implication

Review highlights proteomic approaches to fungal host-pathogen interactions, suggesting novel avenues for developing targeted diagnostics and antifungal therapeutics.

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Cite This Study

Santi et al. (2026) studied this question.

synapsesocial.com/papers/6a993586636c6408cfa7dd2e https://doi.org/10.3390/jof12090647

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Proteomic Studies of Pathogenic Fungi and Hosts: A Multidisciplinary Approach to Therapeutics, Diagnostics, and Host Interactions

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Proteomic Studies of Pathogenic Fungi and Hosts: A Multidisciplinary Approach to Therapeutics, Diagnostics, and Host Interactions

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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