Preventive Cardiovascular Medication Prescribing Patterns in Menopausal Women

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Menopause (n=719272). Intervention: Surgical menopause vs. Nonsurgical menopause. Primary outcome: Statin prescription rate at 5 years (OR 1.22, 95% CI 1.14-1.30, p=<.0001).

Q: What does this research mean for the field?

Women with surgical menopause are prescribed preventive cardiovascular medications, including statins, antihypertensives, and diabetes medications, at significantly higher rates than age- and comorbidity-matched women with nonsurgical menopause. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Amanda Chang; Trisha Slehria; Jennah Johnson; Miquela Teske; Hannah O’Neill; Evelyn Ross-Shapiro; Wendy Fiordellisi

doi:10.1016/j.mayocpiqo.2026.100754

September 1, 2026Mayo Clinic Proceedings Innovations Quality & OutcomesOpen Access

Preventive Cardiovascular Medication Prescribing Patterns in Menopausal Women

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Key result

Surgical menopause was associated with significantly higher 5-year prescription rates for statins (OR 1.22), antihypertensives (OR 1.36), and diabetes medications (OR 1.35) versus nonsurgical menopause.

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Why the study?

To characterize longitudinal prescribing patterns of preventive cardiovascular medications among women with nonsurgical versus surgical menopause to better identify potential differences in care.

Does surgical menopause compared to nonsurgical menopause affect the prescription rates of preventive cardiovascular medications in women?

Study Design

Type

Cohort (n=719,272)

Multicenter

Yes

Structured PICO

Does surgical menopause compared to nonsurgical menopause affect the prescription rates of preventive cardiovascular medications in women?

P

Population

719,272 women with surgical or nonsurgical menopause, evaluated over a 5-year period to characterize longitudinal prescribing patterns of preventive cardiovascular medications.

E

Exposure

Surgical menopause (bilateral oophorectomy)

C

Comparator

Nonsurgical (natural) menopause

O

Outcome

Prescription rates of statin, antihypertensive, and diabetes medications over 5 years

Main Result

Odds Ratio: 1.22 (95% CI 1.14–1.3)

Absolute Event Rate: 7.2% vs 6%

p-value: p=<.0001

Women with surgical menopause receive preventive cardiovascular medications at higher rates than those with natural menopause, suggesting differences in perceived cardiovascular risk by providers.

Limitations

Diagnoses are limited by the accuracy of ICD-10 coding in the TriNetX database
Undercoding of nonsurgical menopause in electronic health record datasets
Nonsurgical menopause group may represent a subset of women who sought care specifically for menopausal symptoms, limiting generalizability
Lack of a physiologic male control cohort
Menopausal hormone therapy (MHT) was not an exclusion criterion and may confound the observed differences
Diagnoses limited by accuracy of ICD-10 coding
Under-coding of nonsurgical menopause in electronic health record data sets
Menopausal hormone therapy (MHT) was not an exclusion criterion and may confound results
Lack of physiologic male control cohort

Implication

Surgical menopause may signal higher cardiovascular risk warranting vigilance; leaves open causal confirmation in prospective studies.

Abstract

Objective To characterize longitudinal prescribing patterns of preventive cardiovascular medications among women with nonsurgical menopause and women with surgical menopause to better identify potential differences in care. Patients and Methods We conducted a retrospective multicenter review using TriNetX from January 27, 2006, to January 27, 2026 (TriNetX analyzes up to 20 years of data before the analysis date). Nonsurgical and surgical menopause patients were compared regarding statin, antihypertensive, and diabetes medication prescription rates over 5 years. Prescribing patterns were additionally analyzed based on medication classes. Results A total of 690,799 nonsurgical menopause patients and 28,473 surgical menopause patients were queried. Nonsurgical menopausal women consistently had lower rates of statin (6.0%), antihypertensive (17.1%), and diabetes medications (7.7%) over 5 years than surgical menopause patients ( P <.0001). Conclusion Surgical menopause patients had higher rates of statin, antihypertensive, and diabetes prescriptions than nonsurgical menopause patients matched by age and comorbidities. Providers should be cognizant of the interplay between menopause status and cardiovascular risk when prescribing preventive cardiovascular medications.

Discussion

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Cite This Study

Chang et al. (2026) conducted a cohort in Menopause (n=719,272). Surgical menopause vs. Nonsurgical menopause was evaluated on Statin prescription rate at 5 years (OR 1.22, 95% CI 1.14-1.30, p=<.0001). Surgical menopause was associated with significantly higher 5-year prescription rates for statins (OR 1.22), antihypertensives (OR 1.36), and diabetes medications (OR 1.35) versus nonsurgical menopause.

synapsesocial.com/papers/6a9935d8636c6408cfa7e532 https://doi.org/10.1016/j.mayocpiqo.2026.100754

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Preventive Cardiovascular Medication Prescribing Patterns in Menopausal Women

Figures

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Preventive Cardiovascular Medication Prescribing Patterns in Menopausal Women

Figures

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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