Genetic screening study evaluates PRKN, PINK1, and DJ-1 variants in Colombian early-onset Parkinson disease, highlighting the need to diversify South American genomic research.
Early-onset Parkinson disease (EOPD), defined as symptom onset before 50 years of age, accounts for approximately 10% of patients and is suggested to have a greater genetic component than typical late-onset forms of the disease. Recessive variants in PRKN, PINK1, and DJ-1, are the most common genetic cause of EOPD, however, most studies are in patients of white ancestry. This study aims to analyze genetic variants in PRKN, PINK1, and DJ-1 in Colombian patients to help address the gap in EOPD genetic research of South American populations.
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Franz et al. (2026) studied this question.
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