Experimental study demonstrates that plant extracts inhibit copper-doped calcium oxalate crystal growth in gel media, highlighting their therapeutic potential against kidney stones.
Copper-doped calcium oxalate (Cu-doped CaOx) crystals were grown by the single-diffusion gel technique and characterized to evaluate the effects of Cu2+ incorporation. XRD confirmed retention of the calcium oxalate monohydrate phase with slight lattice distortion, while FTIR indicated minor changes in the local bonding environment. UV–Visible analysis revealed Cu2+-related electronic transitions, and TG–DTA demonstrated a three-stage decomposition with slightly improved thermal stability. Furthermore, Couroupita guianensis and Ficus religiosa leaf extracts effectively inhibited crystal growth by reducing crystal size, weight, and aggregation in a concentration-dependent manner, highlighting their potential as natural inhibitors of calcium oxalate crystallization.
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Priadharshini et al. (2026) studied this question.
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