What does this research mean for the field?

Cerebrospinal fluid miRNA profiling is a feasible liquid biopsy approach for vestibular schwannoma assessment, although miRNA expression in tumor tissue does not directly correlate with that found in the cerebrospinal fluid. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify a characteristic microRNA expression profile in the cerebrospinal fluid of vestibular schwannoma patients and evaluate its potential for liquid biopsy assessment.

September 3, 2026Non-Coding RNAOpen Access

Cerebrospinal Fluid miRNA Profiling as a Potential Liquid Biopsy for Vestibular Schwannomas

View Full Paper

Ask AI

Bookmark

Authors

MLMałgorzata LitwiniukMedical University of Warsaw MMMaria MakuszewskaMedical University of Warsaw RBRobert BartoszewiczMedical University of Warsaw

Discussion

Member takes

Implication

Prospective study reveals distinct cerebrospinal fluid microRNA profiles in vestibular schwannoma patients, indicating the feasibility of liquid biopsy despite tissue expression discordance.

Key Points

To identify a characteristic microRNA expression profile in the cerebrospinal fluid of vestibular schwannoma patients and evaluate its potential for liquid biopsy assessment.
Conducted a prospective study analyzing 17 cerebrospinal fluid and matched tumor tissue samples (7 small and 10 large tumors) from patients operated on for vestibular schwannoma at a tertiary academic center.
Performed high-throughput RNA sequencing (NovaSeq 6000 Illumina), normalized expression data against healthy donor datasets, and mapped functional implications via KEGG pathway enrichment analysis.
Identified 1633 miRNAs in patient cerebrospinal fluid, demonstrating a moderate ranking correlation with healthy donors (ρ = 0.39) and significant shifts in molecules including hsa-miR-766-3p and hsa-miR-182-5p.
Detected poor direct concordance between fluid and tumor tissue, with only six miRNAs positively correlating, 16 negatively correlating, and no statistically significant correlation observed between tumor size and fluid profiles.
Demonstrated significant functional pathway enrichment in neurotrophin signaling and focal adhesion networks.

Cite This Study

Litwiniuk et al. (2026) studied this question.

synapsesocial.com/papers/6a9935e5636c6408cfa7e8ee https://doi.org/10.3390/ncrna12050035

View Full Paper

Ask AI

Bookmark

Implication

Prospective study reveals distinct cerebrospinal fluid microRNA profiles in vestibular schwannoma patients, indicating the feasibility of liquid biopsy despite tissue expression discordance.

Cerebrospinal Fluid miRNA Profiling as a Potential Liquid Biopsy for Vestibular Schwannomas

Discussion

Member takes

Implication

Key Points

Cite This Study

Cerebrospinal Fluid miRNA Profiling as a Potential Liquid Biopsy for Vestibular Schwannomas

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider