Key result
Transfemoral valve-in-valve TAVI yields 1-year clinical stability and hemodynamic improvement in healed prosthetic endocarditis.
Why the study?
Redo surgery remains standard for prosthetic valve endocarditis complicated by severe prosthetic dysfunction and paravalvular leak, but some patients face prohibitive operative risk.
Does transfemoral valve-in-valve transcatheter aortic valve implantation improve haemodynamics and clinical stability in a patient with healed prosthetic valve endocarditis and severe residual prosthetic valve dysfunction?
Case Report (n=1)
No
Does transfemoral valve-in-valve transcatheter aortic valve implantation improve haemodynamics and clinical stability in a patient with healed prosthetic valve endocarditis and severe residual prosthetic valve dysfunction?
Valve-in-valve TAVI may serve as a viable rescue option for carefully selected patients with healed prosthetic valve endocarditis and prohibitive surgical risk.
May offer rescue valve-in-valve TAVI for prohibitive-risk healed prosthetic valve endocarditis; hypothesis-generating and requires prospective validation.
Background Prosthetic valve endocarditis (PVE) is associated with substantial morbidity and mortality, particularly when complicated by severe prosthetic valve dysfunction and paravalvular leak. Although redo surgery remains the standard treatment, some patients may be unsuitable for surgical intervention because of prohibitive operative risk. Case summary A 64-year-old man with previous surgical bioprosthetic aortic valve replacement had a history of Enterococcus faecalis prosthetic valve endocarditis (PVE) and received targeted antimicrobial therapy. Following targeted antimicrobial therapy with documented microbiological control, he presented with cardiogenic shock due to severe residual prosthetic valve dysfunction, including severe prosthetic stenosis, severe central transprosthetic regurgitation, and severe paravalvular leak. Given his prohibitive surgical risk, the multidisciplinary Heart Team selected transfemoral valve-in-valve transcatheter aortic valve implantation as a rescue strategy. The procedure resulted in marked haemodynamic improvement with only mild residual regurgitation. At 1-year follow-up, the patient remained clinically stable with a well-functioning prosthetic valve and no evidence of recurrent infection. Discussion This case demonstrates that valve-in-valve transcatheter implantation may be considered as a rescue option in carefully selected patients with controlled prosthetic valve endocarditis and residual prosthetic valve dysfunction who are unsuitable for redo surgery. Multimodality imaging and multidisciplinary Heart Team evaluation are essential for individualized decision-making in this challenging clinical scenario.
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Fu et al. (2026) conducted a case report in Healed Enterococcus faecalis prosthetic valve endocarditis with severe residual prosthetic valve dysfunction and paravalvular leak (n=1). Transfemoral valve-in-valve transcatheter aortic valve implantation was evaluated on Clinical and haemodynamic improvement. Transfemoral valve-in-valve transcatheter aortic valve implantation resulted in marked haemodynamic improvement and clinical stability at 1-year follow-up in a patient with healed prosthetic valve endocarditis.
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