An efficient and practical approach was developed to synthesize 1,2,3-triazoles using recyclable Fe3O4 magnetic nanoparticle (MNP)-supported copper(I) catalysts via a one-pot multi-component copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in water. Under microwave irradiation conditions, terminal alkynes reacted quickly with benzyl/alkyl azides, which were generated in situ from corresponding primary halides and sodium azide. The 1,2,3-triazoles can be exclusively generated in good to excellent yields and on a multi-gram scale.
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Xiong et al. (2013) studied this question.
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