Comparative values of phosphatases and other serum enzymes in following patients with prostatic carcinoma.Consideration of phosphohexose isomerase, glutamic oxalacetic transaminase, isocitric dehydrogenase, and acid and alkaline phosphatases

D enzymes corresponding to metabolically involved enzymes in tissue have been studied as a reflection of neoplastic disease.' These enzymes are widely distributed in the tissues and are therefore not strictly specific for neoplastic disease or for the tissue site of such a disease. T h e levels of these enzymes in serum may vary with the clinical state of the patient because of differences in the concentrations of these enzymes in various organs, the size of the organs, and the type of damage to the organ and other factors. T h e question therefore arises whether the concurrent determination of the levels of several serum enzymes may not yield more specific information concerning the nature of the lesion and the progress of the disease than isolated determinations.