Key result
The rs11207997 T allele in the ANGPTL3 gene was associated with a 10% lower risk of developing diabetes mellitus (HR 0.901) compared to the CC genotype.
Why the study?
The role of ANGPTL3 in blood lipids, cardiovascular risk, and glucose metabolism has received wide attention, but its association with diabetes risk and modification by diet was unclear.
Does the T minor allele of the rs11207997 variant in ANGPTL3 reduce the 10-year risk of diabetes mellitus in Korean adults?
Cohort (n=7,358)
Does the T minor allele of the rs11207997 variant in ANGPTL3 reduce the 10-year risk of diabetes mellitus in Korean adults?
The T minor allele of the ANGPTL3 rs11207997 variant is associated with a lower 10-year risk of diabetes in Korean adults, an effect potentially mediated by lifelong lower triglyceride levels and modified by dietary factors.
Answers are grounded in this paper and cite their sources.
Does not support genotyping for diabetes prevention; leaves open causal validation and broader applicability.
The role of angiopoietin-like 3 (ANGPTL3) in blood lipid levels, cardiovascular disease risk, and glucose metabolism has received wide attention. This study aimed to examine whether rs11207997 in ANGPTL3 is associated with a 10-year risk of diabetes mellitus (DM) and if the association is modified by the consumption of certain food groups or nutrients. A prospective cohort study was designed using the Ansan-Ansung data of the Korean Genome and Epidemiology Study (n = 7,358; age ≥40 years at baseline). Participants with the T allele of rs11207997, particularly TT homozygotes, had lower triglyceride (TG) and total cholesterol levels than those with CC. There was no association with fasting blood glucose or other biochemical parameters. ANGPTL3 mRNA was positively associated with circulating TG levels and blood pressure (all p < 0.05). Cox proportional hazard models showed that the rs11207997 T allele is associated with a lower risk of DM after adjusting for covariates (hazard ratio: 0.90, 95% confidence interval: 0.812-0.998, p = 0.046). Furthermore, the association between rs11207997 and the risk of DM was modified by dietary factors. These associations were no longer statistically significant when additionally adjusted for baseline TG, a potential mediator. Our data suggest that genetic variation of rs11207997 in the ANGPTL3 gene is associated with risk of DM, possibly through contributing to a lifelong set point of TG.
No takes yet. Share an insight, caveat, or question.
Park et al. (2019) conducted a cohort in Diabetes mellitus (n=7,358). rs11207997 T allele in ANGPTL3 vs. CC genotype was evaluated on Incidence of diabetes mellitus (HR 0.901, 95% CI 0.812-0.998, p=0.046). The rs11207997 T allele in the ANGPTL3 gene was associated with a 10% lower risk of developing diabetes mellitus (HR 0.901) compared to the CC genotype.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: