Abstract 1,3‐Dipolar cycloadditions of C‐carboxymethyl‐N‐arylnitrile imines with cyclic α,β‐unsaturated ketones of various sizes have been studied. After cycloaddition, oxidative aromatization gives the ring‐fused pyrazoles. Computational studies and the use of topological analyses of the Fukui functions allows a theoretical description of the local reactivity that is in agreement with the experimentally observed regiochemistry.
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Chandanshive et al. (2011) studied this question.
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