Key result
In a piglet model of cardiac arrest, PBN and S-PBN demonstrated neuroprotective effects by enhancing neurological outcome, decreasing oxidative damage, and improving cerebral blood flow autoregulation.
Why the study?
Does PBN or S-PBN improve neurological outcome and reduce oxidative damage in a piglet model of circulatory arrest?
Population
Piglets weighing approximately 25 kg subjected to ventricular fibrillation for 8-12 min followed by…
Design
Preclinical
Follow-up
>24 h
Authors
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Does not support clinical use; leaves open translation of neuroprotective effects to human cardiac arrest.
Does PBN or S-PBN improve neurological outcome and reduce oxidative damage in a piglet model of circulatory arrest?
PBN and S-PBN demonstrate neuroprotective effects in a piglet model of circulatory arrest, suggesting potential as therapeutic agents for global ischemic injury.
Wiklund et al. (2005) studied Cardiac arrest and global ischemic injury. PBN (alpha-phenyl-N-tert-butyl nitrone) and S-PBN was evaluated on Neurological outcome, plasma concentrations of 8-iso-PGF(2alpha), and cerebral cortical blood flow. In a piglet model of cardiac arrest, PBN and S-PBN demonstrated neuroprotective effects by enhancing neurological outcome, decreasing oxidative damage, and improving cerebral blood flow autoregulation.
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