The association of two high-molecular-weight hyaluronan (HA) derivatives, namely a beta-cyclodextrin (HA-beta-CD) and an N-acylurea (EDC-HA), dissolved in aqueous NaCl, was studied. The weight-average of the molecular weights (Mw) of HA-beta-CD and of EDC-HA was 185.3 and 86.8 kDa, respectively. However, the Mw value determined for the equimolar mixture of the two biopolymers equaled 556.0 kDa. Similarly, the radius of gyration (dimension) Rg = 80.6 nm of the above equimolar mixture was significantly greater than the values found for the single macromolecules, i.e., 40.2 nm for HA-beta-CD and 23.8 nm for EDC-HA. These data indicate that the two kinds of substituents, borne by the HA polymeric chains, form host-guest inclusion complexes resulting in polymacromolecular associates/aggregates.
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Šoltés et al. (2004) studied this question.
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