The unique hexacyclic cagelike structure of (+)-gelsemine (1) has been accomplished. The first enantioselective total synthesis of this alkaloid features a facile construction of the bicyclo[3.2.1] core by means of two rearrangement reactions and the efficient formation of the pyrrolidine ring by an intramolecular Michael addition. Bn=Benzyl.
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Yokoshima et al. (2000) studied this question.
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