A one pot synthesis of peptides with free C-terminal residues has been accomplished via the active Se-phenyl carboselenoate using diphenyl diselenide, tributylphosphine, and N-methylmorpholine N-oxide in an acetonitrile– water mixed solvent system. Free amino acids and peptides have been used as the amine component without pH adjustment.
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Ghosh et al. (1993) studied this question.
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