SUMMARY Minimum lethal concentrations (MLC) and minimum inhibitory concentrations (MIC) were determined in vitro for 8 antibiotics against 9 isolates of Mycoplasma synoviae. Of the antibiotics tested, tylosin had the highest activity, followed closely by chlortetracycline, lincomycin, oxytetracycline, spectinomycin, and tetracycline. Neomycin and erythromycin were less effective. Two antibiotic combinations (lincomycin-spectinomycin and oxytetracyclineneomycin) had greater mycoplasmacidal activity than either member of the combination acting alone.
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Kleven et al. (1971) studied this question.
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