Trials were conducted to compare Micotil (tilmicosin) to other antibiotics available for the treatment of bovine respiratory disease. Tilmicosin (10 mg/kg body weight) was more effective than oxytetracycline (20 mg/kg) at lowering the temperature of affected cattle on the first day of treatment and showed a lower mortality rate. Tilmicosin gave better results than oxytetracycline (4 and 7 mg/lb), ceftiofur (0.5 mg/lb) and trimethoprim (1.2 mg)/sulfadoxine (6 mg/lb) with regard to first treatment success rate, numbers of animals becoming chronic, numbers developing fibrinous pneumonia and average treatment days per animal.
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Merrill et al. (1989) studied this question.