In in vitro tissue cultures of human bone tumors (osteoclastomas, chondroblastomas) containing numerous multinucleated cells, the finding of tri-, quadri- and other types of multipolar mitosis has been studied. The presence of multipolar mitosis in the cultures and its role in the formation of multinucleated cells suggest the existence of a combined mechanism of mitosis and fusion for the formation of multinucleated cells in human bone tumors in in vitro tissue cultures.
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Troise et al. (2009) studied this question.
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