Key result
Fibrin-associated large B-cell lymphoma causes transcatheter valve failure, successfully resolved with surgical explantation.
Why the study?
Fibrin-associated large B-cell lymphoma is a rare disorder, and its role in transcatheter valve failure was unknown.
Case Report (n=1)
No
This case establishes fibrin-associated large B-cell lymphoma as a rare but curable neoplastic cause of structural valve degeneration in transcatheter bioprosthetic valves.
Alerts clinicians to rare lymphoma in unexplained TAVR SVD; hypothesis-generating, leaves open incidence and surveillance needs.
BACKGROUND: Fibrin-associated large B-cell lymphoma (FA-LBCL) is a rare disorder, but its role in transcatheter valve failure is unknown. This report describes the first documented case of FA-LBCL in a transcatheter aortic valve. FIRST-IN-HUMAN/EARLY REPORTS SUMMARY: A 62-year-old man with a prior transcatheter aortic valve replacement presented with symptomatic severe aortic stenosis. Histopathologic analysis of the explanted valve revealed FA-LBCL as the primary cause of valve failure. DISCUSSION: This case established a neoplastic process as a cause of structural valve degeneration (SVD) in transcatheter valves. It highlights that FA-LBCL should be included in the differential diagnosis of transcatheter aortic valve replacement failure, for which surgical explantation can be both diagnostic and curative. NOVELTY: This is the first report that documents FA-LBCL causing SVD of a transcatheter bioprosthetic valve. TAKE-HOME MESSAGES: FA-LBCL represents a cause of SVD in transcatheter bioprosthetic valves. This diagnosis should be considered in cases of premature valve failure.
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Tharakan et al. (2025) conducted a case report in Structural valve degeneration (n=1). Fibrin-associated large B-cell lymphoma (FA-LBCL) was evaluated on Cause of transcatheter valve failure / structural valve degeneration. Fibrin-associated large B-cell lymphoma was identified as a novel cause of structural valve degeneration in a transcatheter bioprosthetic valve, successfully treated with surgical explantation.
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