Key result
Analysis of 722 influenza C virus sequences revealed no evidence of homologous recombination, suggesting it plays little or no role in the evolution of the virus.
Homologous recombination appears to have minimal or no effect on influenza C virus evolution.
Supports negligible recombination in influenza C; leaves open its role in other respiratory viruses and surveillance priorities.
The occurrence of homologous recombination in influenza viruses has been under some debate recently. To determine the extent of homologous recombination in influenza C virus, recombination analyses of all available gene sequences of influenza C virus were carried out. No recombination signal was found. With the previous evidence in influenza A and B viruses, it seems that homologous recombination has minimal or no effect on influenza virus evolution.
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Han et al. (2010) studied Influenza C virus (n=722). Homologous recombination was evaluated on Recombination signals detected by 3SEQ, Bruen's F, Chimaera, GENECONV, and RDP. Analysis of 722 influenza C virus sequences revealed no evidence of homologous recombination, suggesting it plays little or no role in the evolution of the virus.
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