individuals with CF. Intrinsic resistance to the aminoglycosides is related to lack of binding to lipopolysaccharide in the outer membrane Resistance to the -lactam antibiotics appears to be caused by synergistic mechanisms, including the induction of chromosomal -lactamases (12, 13) and decreased drug access Other mechanisms of resistance may also be related to diminished antibiotic access (16), including drug efflux (17).
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Nair et al. (2004) studied this question.
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