23 individual flavonoids and 23 flavonoid mixtures were assayed for their inhibition of the high K m cyclic AMP phosphodiesterase (PDE) in rat heart. Some of the flavonoids showed I 50 in the micromolar range whereas others were less potent. The enzyme inhibition was of noncompetitive type. Some of the flavonoid mixtures showed an inhibitory activity comparable to that of the most potent individual compounds. Key Word Index Flavonoids - Flavonoid Mixtures - cAMP Phosphodiesterase Inhibitors
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Petkov et al. (1981) studied this question.