Why the study?
Do changes in cardiac troponin I levels over 48 hours predict mortality in conservatively managed NSTE-ACS patients?
Cohort (n=1,615)
Yes
Do changes in cardiac troponin I levels over 48 hours predict mortality in conservatively managed NSTE-ACS patients?
Answers are grounded in this paper and cite their sources.
A lack of relevant decrease in moderately increased cTnI levels over 48 hours is predictive of higher 30-day and 1-year mortality in conservatively managed NSTE-ACS patients.
OBJECTIVE: Information is limited on the prognostic implications of cardiac troponin I (cTnI) changes during the first days of non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: High-sensitivity cTnI levels were measured at study inclusion and after 48 h in 1615 conservatively managed NSTE-ACS patients from the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV trial. RESULTS: Patients with moderately increased cTnI levels and without a relevant decrease over time had a significantly raised mortality at 30 days and 1 year. No relevant associations between cTnI changes and recurrent myocardial infarction were seen. CONCLUSION: The cTnI change is predictive for subsequent mortality in selected conservatively managed NSTE-ACS patients.
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Eggers et al. (2013) conducted a cohort in non-ST elevation acute coronary syndrome (NSTE-ACS) (n=1,615). Moderately increased cTnI levels without a relevant decrease over 48 hours was evaluated on Mortality at 30 days and 1 year.
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