Key result
The rapid accrual of new conditions in patients with nonvalvular atrial fibrillation carried a 39% higher risk of death, heart failure, major bleeding, and stroke or systemic embolism (HR 1.39).
Why the study?
Does worsening multimorbidity increase the risk of adverse clinical outcomes in patients with nonvalvular atrial fibrillation?
Does worsening multimorbidity increase the risk of adverse clinical outcomes in patients with nonvalvular atrial fibrillation?
Worsening multimorbidity in patients with atrial fibrillation significantly increases the risk of death and heart failure, underscoring the need for continuous, integrated risk-factor management rather than static baseline assessment.
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Alben et al. (2026) conducted an editorial in Nonvalvular Atrial Fibrillation (n=3,096). Rapid accrual of new conditions (worsening multimorbidity) vs. Stable multimorbidity was evaluated on Composite of death, heart failure, major bleeding, and stroke or systemic embolism (HR 1.39, 95% CI 1.13-1.71). The rapid accrual of new conditions in patients with nonvalvular atrial fibrillation carried a 39% higher risk of death, heart failure, major bleeding, and stroke or systemic embolism (HR 1.39).
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