Key result
Adult adiposity measured by BMI was negatively associated with premenopausal breast cancer risk (OR per 1 kg/m2 = 0.93), although central obesity increased risk among normal-weight women.
Why the study?
Evidence suggests height and adiposity relate to premenopausal breast cancer risk in Caucasian women, but data from Latin America are scarce.
Does excess adiposity and body shape evolution affect the risk of premenopausal breast cancer in Latin American women?
Case-Control (n=812)
Yes
Does excess adiposity and body shape evolution affect the risk of premenopausal breast cancer in Latin American women?
Odds Ratio: 0.93 (95% CI 0.89–0.96)
p-value: p=<0.01
In Latin American premenopausal women, overall adult adiposity was negatively associated with breast cancer risk, though central obesity in normal-weight women increased risk.
This is the authors' abstract. We don't add key points for this paper.
Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20–45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89–0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69–0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67–0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47–8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98–1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.
Should not yet change risk assessment in Latin American women; extends Caucasian data on adiposity but leaves open causal confirmation.
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His et al. (2020) conducted a case-control in Premenopausal breast cancer (n=812). Adult adiposity (Body Mass Index) vs. Lower adiposity was evaluated on Risk of premenopausal breast cancer (OR 0.93, 95% CI 0.89-0.96, p=<0.01). Adult adiposity measured by BMI was negatively associated with premenopausal breast cancer risk (OR per 1 kg/m2 = 0.93), although central obesity increased risk among normal-weight women.
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